Rookie FBI agent Jo Dee Foster has been assigned to work on the case of the Psycho Killer, a psycho killer who has psycho-killed over 120 people. But to learn more about his target, he's forced to meet Dr. Animal Cannibal Pizza, a famous doctor turned cannibal who ate pizzas with human body parts. Meanwhile, Jo's girlfriend, Jane Wine, has just stolen $400,000 in cash from her money-hungry boss, Mr. Laurel, so she and Jo can be happy, but gets lost in a horrible storm and stops at the Cemetery Motel, where the owner, Antonio Motel, is dominated by his insane mother.
