Uncle's Palm Pet follows Fang Wan (played by Guo Yuxin), a recent college graduate whose manipulative adoptive mother attempts to drug her and sell her for money. While escaping, Fang Wan crosses paths with Song Yubai (played by Zhou Yufei), the wealthy second son of the Song family, who has also been drugged as part of a plot by his scheming brother.
To protect themselves and solve their immediate problems, the two agree to enter a quick marriage of convenience. After severing ties with her toxic family, Fang Wan settles into life with Song Yubai. As Song Yubai pampers and defends Fang Wan against external threats, their transactional arrangement gradually blossoms into genuine love.
